Spreading depression as a preclinical model of migraine
نویسندگان
چکیده
منابع مشابه
Familial Hemiplegic Migraine and Spreading Depression
OBJECTIVE Familial hemiplegic migraine (FHM) is an autosomal dominantly inherited subtype of migraine with aura, characterized by transient neurological signs and symptoms. Typical hemiplegic migraine attacks start in the first or second decade of life. Some patients with FHM suffer from daily recurrent attacks since childhood. Results from extensive studies of cellular and animal models have i...
متن کاملMigraine generator network and spreading depression dynamics as neuromodulation targets in episodic migraine.
Migraine is a common disabling headache disorder characterized by recurrent episodes sometimes preceded or accompanied by focal neurological symptoms called aura. The relation between two subtypes, migraine without aura (MWoA) and migraine with aura (MWA), is explored with the aim to identify targets for neuromodulation techniques. To this end, a dynamically regulated control system is schemati...
متن کاملfamilial hemiplegic migraine and spreading depression
how to cite this article: kazemi h, speckmann ej, gorji a. familial hemiplegic migraine and spreading depression. iran j child neurol. 2014 summer;8(3): 6-11. abstract objective familial hemiplegic migraine (fhm) is an autosomal dominantly inherited subtype of migraine with aura, characterized by transient neurological signs and symptoms. typical hemiplegic migraine attacks start in the first...
متن کاملP141: The Role of Microglia in Cortical Spreading Depression in Migraine
Migraine is a disorder that afflicts nearly one tenth of the population. Involving both nervous and vascular system, it has been found as a prominent factor of disability. The migraine attacks may be initiated in the brainstem or may begin peripherally in the meninges while the role of cortical activation preceding an attack is also debated. Although available treatments, more studies on migrai...
متن کاملLinking a genetic defect in migraine to spreading depression in a computational model
Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. A mutation causing FHM type 3 (FHM3) has been identified in SCN1A encoding the Nav1.1 Na(+) channel. This genetic defect affects the inactivation gate. While the Na(+) tail currents following voltage steps are consistent with both hyperexcitability and hypoexcitability, in this computational study, we investigate functi...
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ژورنال
عنوان ژورنال: The Journal of Headache and Pain
سال: 2019
ISSN: 1129-2369,1129-2377
DOI: 10.1186/s10194-019-1001-4